Showing posts with label bacteria. Show all posts
Showing posts with label bacteria. Show all posts

02 July 2007

Open Source Life

Fascinating:

Whatever Carl Woese writes, even in a speculative vein, needs to be taken seriously. In his "New Biology" article, he is postulating a golden age of pre-Darwinian life, when horizontal gene transfer was universal and separate species did not yet exist. Life was then a community of cells of various kinds, sharing their genetic information so that clever chemical tricks and catalytic processes invented by one creature could be inherited by all of them. Evolution was a communal affair, the whole community advancing in metabolic and reproductive efficiency as the genes of the most efficient cells were shared. Evolution could be rapid, as new chemical devices could be evolved simultaneously by cells of different kinds working in parallel and then reassembled in a single cell by horizontal gene transfer.

But then, one evil day, a cell resembling a primitive bacterium happened to find itself one jump ahead of its neighbors in efficiency. That cell, anticipating Bill Gates by three billion years, separated itself from the community and refused to share. Its offspring became the first species of bacteria—and the first species of any kind—reserving their intellectual property for their own private use. With their superior efficiency, the bacteria continued to prosper and to evolve separately, while the rest of the community continued its communal life. Some millions of years later, another cell separated itself from the community and became the ancestor of the archea. Some time after that, a third cell separated itself and became the ancestor of the eukaryotes. And so it went on, until nothing was left of the community and all life was divided into species. The Darwinian interlude had begun.

22 January 2007

Open Source Bacteria

Another reason to understand openness:

When a team of geneticists unlocked the secret of the bug's rapid evolution in 2005, they found that one strain of multidrug-resistant Acinetobacter baumannii carries the largest collection of genetic upgrades ever discovered in a single organism. Out of its 52 genes dedicated to defeating antibiotics, radiation, and other weapons of mass bacterial destruction, nearly all have been bootlegged from other bad bugs like Salmonella, Pseudomonas, and Escherichia coli.

In the open source world of bacteria, everyone is working for the resistance.

15 November 2006

The Problems of a Synthetic Biology Commons

Here's a fascinating paper:

Novel artificial genetic systems with twelve bases instead of four. Bacteria that can be programmed to take photographs or form visible patterns. Cells that can count the number of times they divide. A live polio virus "created from scratch using mail-order segments of DNA and a viral genome map that is freely available on the Internet." These are some of the remarkable, and occasionally disturbing, fruits of "synthetic biology," the attempt to construct life starting at the genetic level.

All good stuff, but there's a problem that may be of interest to readers of these posts:

synthetic biology raises with remarkable clarity an issue that has seemed of only theoretical interest until now. It points out a tension between different methods of creating "openness". On the one hand, we have intellectual property law’s insistence that certain types of material remain in the public domain, outside the world of property. On the other, we have the attempt by individuals to use intellectual property rights to create a "commons," just as developers of free and open source software use the leverage of software copyrights to impose requirements of openness on future programmers, requirements greater than those attaching to a public domain work. Intellectual property policy, at least in the United States, specifies things that cannot be covered by intellectual property rights, such as abstract ideas or compilations of unoriginal facts, precisely to leave them "open" to all – the public roads of the intellect. Yet many of the techniques of open source require property rights so that future users and third parties will be bound by the terms of the license. Should we rethink the boundary lines between intellectual property and the public domain as a result?