Showing posts with label googling the genome. Show all posts
Showing posts with label googling the genome. Show all posts

20 March 2009

Coming to an ID Card Near You: Your DNA

One of the many disgraceful aspects about the disgraceful ID card programme is the reluctance of the UK government to make key documents available. For such a momentous change in the relationship of government to governed, it is critically important that a full debate about all the issues be conducted; but without key details of the scheme, that is made more difficult – which is presumably why the UK government has resisted the publication of the so-called “Gateway reviews” so long.

Finally, though, we have gained the right to see these somewhat outdated documents. Despite their age, and the unnecessary redactions, some useful new information has come to light, which more than justifies the long battle to gain access.

On Open Enterprise blog.

06 October 2008

Googling the Genome

We're getting close:

The cost of determining a person’s complete genetic blueprint is about to plummet again — to $5,000.

That is the price that a start-up company called Complete Genomics says it will start charging next year for determining the sequence of the genetic code that makes up the DNA in one set of human chromosomes. The company is set to announce its plans on Monday.

Such a price would represent another step toward the long-sought goal of the “$1,000 genome.” At that price point it might become commonplace for people to obtain their entire DNA sequences, giving them information on what diseases they might be predisposed to or what drugs would work best for them.

03 March 2008

Really Googling the Genome

When I wrote a piece for the Guardian four years ago called "Googling the Genome", it was more of a metaphor than a specific warning about Google rummaging through your DNA. But it's a metaphor no more:

A Harvard University scientist backed by Google Inc. and OrbiMed Advisors LLC plans to unlock the secrets of common diseases by decoding the DNA of 100,000 people in the world's biggest gene sequencing project.

The *first* 100,000 people, I think they mean....

20 October 2007

DNA Vu

Now, where have I heard this before?

Today it costs only $300,000 to sequence a person's DNA, and the $100,000 benchmark is in sight. It's an information processing problem, he said. In other words, Moore's Law and genetics are tightly tied. It won't be long before your genome--and your likelihood to get various diseases, live long, be athletic, etc.--will be available in a standard medical test.

The implications for medicine, and its evil twin the insurance industry, are vast. Despite the privacy issues, Venter is in favor of transparency in genomics, so that, for example, you'll be able to "Google a date's DNA," as O'Reilly remarked. Scary? Sure. But "a good idea," Venter said. "Especially if you plan to have children."

Oh yes, I remember:

Consider a not-too-distant future in which personal genomes are readily available. For those with relations affected by a serious medical condition, this will conveniently provide them with any genetic test they need. But it will also offer the rest of us information about our status for these and other, far less serious, autosomal recessive disorders that might similarly manifest themselves in children if we married a fellow carrier.

A bioinformatics program running on a PC could easily check our genomes for all genes associated with the autosomal recessive disorders that had been identified so far. Regular software updates downloaded from the internet - like those for anti-virus programs - would keep our search software abreast of the latest medical research. The question is, how potentially serious does a variant gene's effects have to be for us to care about its presence in our DNA? Down to what level should we be morally obliged to tell our prospective partners - or have the right to ask about?

And just when is the appropriate moment to swap all these delicate DNA details? Before getting married? Before going to bed together? Before even exchanging words? Will there one day be a new class of small, wireless devices that hold our personal genomic profile in order to carry out discreet mutual compatibility checks on nearby potential partners: a green light for genomic joy, a red one for excessive recessive risks?

Given the daunting complexity of the ethical issues raised by knowing the digital code of life in detail, many may opt for the simplest option: not to google it. But even if you refuse to delve within your genome, there are plenty of others who will be keen to do so. Employers and insurance companies would doubtless love to scan your data before giving you a job or issuing a policy. And if your children and grandchildren have any inconvenient or expensive medical condition that they have inherited from one side of the family, they might like to know which - not least, to ensure that they sue the right person.

19 June 2007

DNA = Do Not Ask

This will end in tears:

Although the ability to conduct a home DNA test and get the results with relative ease are tempting, the thought of sitting across the kitchen table with a distant cousin-husband may be little too weird to down with the morning coffee.

27 May 2007

Googling the Genome, Part III

Good to see some others concerned by the imminent arrival of personal genomics:

In addition, many scientists fear cheap genome sequencing could have other, worrying consequences. Professor Steve Jones of University College London, said: 'If you make your genome public, you are not just revealing information about yourself and what diseases you might be susceptible to, you are also giving away crucial data about the kind of illnesses your children might be prone to. Each of your children gets half your genes, after all. They might not want the world to know about the risks they face and become very unhappy in later life that you went public. Your other relatives might equally be displeased.'

And by its implications for civil liberties:

However, there are other concerns, as Professor Ashburner points out. 'Anyone who commits relatively minor offences can have their DNA taken and analysed. At present, the main use of this process is to create a DNA fingerprint that can be used to identify that individual. But soon we will be able to create an entire genome sequence of that individual from a swab or blood sample. We will end up knowing everything about their genes. In the end, we could have millions of people on a database and know every single genetic secret of each person. That has to be a very worrying prospect.'

23 May 2007

Googling the Genome, Part II

23andMe is a privately held company developing new ways to help you make sense of your own genetic information.

Even though your body contains trillions of copies of your genome, you've likely never read any of it. Our goal is to connect you to the 23 paired volumes of your own genetic blueprint (plus your mitochondrial DNA), bringing you personal insight into ancestry, genealogy, and inherited traits. By connecting you to others, we can also help put your genome into the larger context of human commonality and diversity.

Toward this goal, we are building on recent advances in DNA analysis technologies to enable broad, secure, and private access to trustworthy and accurate individual genetic information. Combined with educational and scientific resources with which to interpret and understand it, your genome will soon become personal in a whole new way.

Nothing special there, of course. What makes this news is the following:

Google said it had invested $3.9 million in the company, called 23andMe Inc., giving the Mountain View, California-based Google a minority stake in the start-up, according to a filing with the U.S. Securities and Exchange Commission.

I wrote about this three years ago, but purely theoretically. Be very afraid. (Via TechCrunch.)

18 July 2006

The Personal Genome Part 265

Here's Nick Wade reviewing candidate technologies for the sub-$1000 genome. It's coming, people.