Why Pig Flu is Better than Bird Flu: Open Data

As I wrote two years ago, one of the most worrying aspects of bird flu (remember that?) was that virus sequences were not being shared well, which meant that it was hard for experts to track its development and come up with a vaccine. Well, in one respect, swine flu seems to be an improvement over the avian variety:

In contrast to H5N1 bird flu, all the genetic sequences of this H1N1 are being posted on bulletin boards like GISAID, where scientists can access them and compare preliminary analyses.

The GISAID system was set up in 2006 by scientists who protested that H5N1 sequences were not being made freely available.

Here's what the GISAID site says:

This platform is designed and maintained by scientists for scientists from various disciplines e.g. veterinary and human virology, bioinformatics, epidemiology, immunology and clinical analysis etc. From here on, you will find a series of services, including the EpiFlu Database (developed by the Swiss Institute of Bioinformatics in conjunction with other partners of this initiative) providing secure storage and the analysis of genetic, epidemiological and clinical data.

Researchers like you have come together to empower this publicly accessible platform, free-of-charge to all researchers in the world who agree to the same terms, to foster a better understanding of the influenza virus. Following the correspondence letter in Nature, we have all pledged to share the data, to analyze the findings jointly, and to publish the results collaboratively, on the basis of open sharing of data respecting the rights and interests of all involved parties.

One fascinating aspect of this is that to view the data you must agree to the data-sharing that lies at the heart of the site:

Before you can enter, you are required to register and agree to the Terms of Use of our platform, as GISAID implements a particular data-sharing concept that has facilitated the flow of influenza sequence data to the public.

This creates an information commons, just as free software does.

Maybe there's hope for us yet.

How Sick Are Patents? Ask Indonesia

Some time back I noted that one of the crazier consequences of an obsession with intellectual monopolies was that vital health information - specifically, DNA sequences of bird flu viruses - were not being released to other laboratories for fear that the unscrupulous might patent the damn things (as if naturally-occuring DNA could be patented). Fortunately, the country in question, Indonesia, was persuaded to release them to the scientific community for the common good. And what happens? This:

A recent patent search has revealed that the CDC, which is a WHO collaborating centre, is applying for a patent for a new vaccine against influenza, particularly for bird flu (H5N1). The vaccine incorporates genes from a H5N1 strain isolated from an Indonesian human victim of bird flu in 2005.

The strain that contains the genes was transferred to the WHO GISN by Indonesia for characterization for public health purposes, but may wind up as the property of the US government.

Under US law, the US government agencies would offer licenses to the technology to pharmaceutical companies. The patent application indicates that the US government intends to pursue the claim in most countries of the world, including Indonesia itself, as well as neighboring countries.

Got that? Indonesia releases the sequences, and the US CDC does indeed patent that information, a situation which could then force Indonesia to pay for vaccines based on its own sequence data to protect its citizens. This probably means that fewer vaccines will be bought, more people will die, more mutations in the flu virus, and more deaths globally. So how, exactly, is this particular intellectual monopoly good for the world?

I just hope that one day a book is written about this, and the people responsible are named - and utterly shamed - for actions that are not only morally despicable in themselves, but which endanger literally the whole of humanity. How sick is that...? (Via How the World Works.)