Pat "Nutter" Brown Strikes Again

To change the world, it is not enough to have revolutionary ideas: you also have the inner force to be able to realise them in the face of near-universal opposition/indifference/derision. Great examples of this include Richard Stallman, who ploughed his lonely GNU furrow for years before anyone took much notice, and Michael Hart, who did the same for Project Gutenberg.

Another of these rare beings with both vision and tenacity is Pat Brown, a personal hero of mine. Not content with inventing one of the most important experimental tools in genomics - DNA microarrays - Brown decided he wanted to do something ambitious: open access publishing. This urge turned into the Public Library of Science (PLoS) - and even that is just the start:

PLoS is just part of a longer range plan. The idea is to completely change the way the whole system works for scientific communication.

At the start, I knew nothing about the scientific publishing business. I just decided this would be a fun and important thing to do. Mike Eisen, who was a post-doc in my lab, and I have been brain-storming a strategic plan, and PLoS was a large part of it. When I started working on this, almost everyone said, “You are completely out of your mind. You are obviously a complete idiot about how publishing works, and besides, this is a dilettante thing that you're doing.” Which I didn't feel at all.

I know I'm serious about it and I know it's doable and I know it's going to be easy. I could see the thermodynamics were in my favor, because the system is not in its lowest energy state. It's going to be much more economically efficient and serve the customers a lot better being open access. You just need a catalyst to GET it there. And part of the strategy to get it over the energy barrier is to apply heat—literally, I piss people off all the time.

In case you hadn't noticed, that little plan "to completely change the way the whole system works for scientific communication" is coming along quite nicely. So, perhaps buoyed up by this, Brown has decided to try something even more challenging:

Brown: ... I'm going to do my sabbatical on this: I am going to devote myself, for a year, to trying to the maximum extent possible to eliminate animal farming on the planet Earth.

Gitschier: [Pause. Sensation of jaw dropping.]

Brown: And you are thinking I'm out of my mind.

Gitschier: [Continued silence.]

Brown: I feel like I can go a long way toward doing it, and I love the project because it is purely strategy. And it involves learning about economics, agriculture, world trade, behavioral psychology, and even an interesting component of it is creative food science.

Animal farming is by far the most environmentally destructive identified practice on the planet. Do you believe that? More greenhouse production than all transportation combined. It is also the major single source of water pollution on the planet. It is incredibly destructive. The major reason reefs are dying off and dead zones exist in the ocean—from nutrient run-off. Overwhelmingly it is the largest driving force of deforestation. And the leading cause of biodiversity loss.

And if you think I'm bullshitting, the Food and Agricultural Organization of the UN, whose job is to promote agricultural development, published a study, not knowing what they were getting into, looking at the environmental impact of animal farming, and it is a beautiful study! And the bottom line is that it is the most destructive and fastest growing environmental problem.

Gitschier: So what is your plan?

Brown: The gist of my strategy is to rigorously calculate the costs of repairing and mitigating all the environmental damage and make the case that if we don't pay as we go for this, we are just dumping this huge burden on our children. Paying these costs will drive up the price of a Big Mac and consumption will go down a lot. The other thing is to come up with yummy, nutritious, affordable mass-marketable alternatives, so that people who are totally addicted to animal foods will find alternatives that are inherently attractive to eat, so much so that McDonald's will market them, too. I want to recruit the world's most creative chefs—here's a REAL creative challenge!

I've talked with a lot of smart people who are very keen on it actually. They say, “You have no chance of success, but I really hope you're successful.” That's just the kind of project I love.

Pat, the world desperately needs nutters like you. Let's just hope that the thermodynamics are in your favour once more.

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Haapy Birthday PLoS

The Public Library of Science did not invent open access, but there's no doubt it took it to the next level:

On the 13th of October in 2003, with the first issue of PLoS Biology, the Public Library of Science realized its transformation from a grassroots organization of scientists to a publisher. Our fledgling website received over a million hits within its first hour, and major international newspapers and news outlets ran stories about the journal, about science communication in general, and about our founders—working scientists who had the temerity to take on the traditional publishing world and who pledged to lead a revolution in scholarly communication (see, for example, [1,2]). It was not only scientists and publishers who wanted to see what this upstart start-up was doing; we had somehow captured the imagination of all sections of society. Not all of the reactions were positive, of course, especially from those in the scientific publishing sector with a vested interest in maintaining the subscription-based system of journal publishing. But thanks in no small part to the efforts of the founders—Pat Brown, Mike Eisen, and Harold Varmus—and an editorial team that included a former editor of Cell and several from Nature, our call for scientists to join the open-access revolution [3,4] did not go unheeded. Five years on, the publishing landscape has changed radically.

But what about the future?

The next challenge—for PLoS Biology, for PLoS and for all open-access publishers—is to demonstrate the utility of open access in advancing science beyond what can be gained from just making the information publicly available to read. The biggest misconception about open access is that it's only about putting online what was in print and removing any toll for access. It's not: it's about having the freedom to reuse that material without restriction [11]. Open-access publishing is therefore a crucial catalyst for a genuine shift in the way we use and mine the literature and integrate it with databases and other means of scientific communication. We are only just beginning to see the start of these: in video-based initiatives such as SciVee (Table 1); in knowledge discovery platforms such as Knewco, OSCAR, and the NeuroCommons (Table 1); with the increasing use of blogging in discourse about scientific research (see, for example, http://researchblogging.org/); and in the emergence of wiki projects in community-based knowledge curation [13,14].

I can't wait. Here's to the next five years.