Open Source Drug Discovery

One of the inspirations for free software was the scientific method. So it's deeply ironic that science finds itself increasingly unable to share information because of concerns about intellectual monopolies - either infringing on them, or losing the power to create them. This is particularly tragic in the field of medical research, because it means that people are suffering, maybe even dying, as a result.

Against that rather dismal background, here's a ray of hope from India:

OSDD is a CSIR Team India Consortium with Global Partnership with a vision to provide affordable healthcare to the developing world by providing a global platform where the best minds can collaborate & collectively endeavor to solve the complex problems associated with discovering novel therapies for neglected tropical diseases like Malaria, Tuberculosis, Leshmaniasis, etc. It is a concept to collaboratively aggregate the biological and genetic information available to scientists in order to use it to hasten the discovery of drugs. This will provide a unique opportunity for scientists, doctors, technocrats, students and others with diverse expertise to work for a common cause.

The success of Open Source models in Information Technology (For e.g., Web Technology, The Linux Operating System) and Biotechnology (For e.g., Human Genome Sequencing) sectors highlights the urgent need to initiate a similar model in healthcare, i.e., an Open Source model for Drug Discovery.

This is a great idea, especially for a country like India that has much to gain from opening up the world of drug development so that people can collaborate on that "common cause", and from refusing to pay exorbitant intellectual monopoly taxes.

It's already produced results:

Indian scientists have mapped the Mycobacterium tuberculosis genome, a first of its kind achievement that gives hope of discovering a cost effective drug for the disease that kills at least 330,000 Indians every year.

"Our scientists along with over 100 science students from several universities have done this within a few months. We hope within 18-24 months we will be able to take one molecule to the clinical trial stage," Council for Scientific and Industrial Research (CSIR) chief Samir Bramhachari told IANS.

...

"OSDD is a completely new formula across the world. Here we are making all our progress available to public. Anyone can take advantage and develop a drug based on our research. The aim here is not patents but drug discovery for a neglected disease," said Rajesh Gokhle, a senior scientist associated with the project.

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Open Source Drug Discovery

There's something utterly perverse about the way new drugs are developed. Pharmaceutical companies spend hundreds of millions - sometimes billions - of Euros investigating vast numbers of new compounds in the hope that they might treat a particular disease. If they find one that works, they then have to test it extensively for side-effects and the rest. Moreover, most of the negative knowledge they acquire - what doesn't work - is wilfully thrown away, since it represents "competitive" information.

But how about turning things on their head? Instead of trying millions of new substances for one disease, how about experimenting with the tens of thousands of known, safe medicines in the public domain on thousands of diseases? Like this:

The Johns Hopkins Clinical Compound Screening Initiative is an open-source effort to collect and index more than 10,000 known medications and determine which of them are also effective against hundreds of low-profile, Third World killers, such as Chagas disease, cholera and leprosy. The library will function something like a Wikipedia of drug discovery, where scientists around the world can contribute to the database and even provide samples or screen drugs themselves, thereby saving millions of dollars on R&D.

This could save millions of lives. Just one problem: nobody gets obscenely rich in the process....